In obese individuals, increased vitamin D accumulation in adipose tissue increases the risk of vitamin D deficiency, so use high doses but with caution for toxicity. Use with caution in patients with elevated levels of calcium and phosphorus in the blood. Note when using Cholecalciferol drug: Using high doses of Cholecalciferol continuously for a long time can cause side effects such as constipation, loss of appetite and fatigue. Patients with primary hyperparathyroidism. Indications of the drug CholecalciferolÄo not use Cholecalciferol in the following cases: Hypercalcemia. The drug is fatty acid soluble and requires bile acid action. Once inside the body, Cholecalciferol binds to cells to regulate the absorption of calcium and phosphorus from food. Sunscreen, sun-protective clothing and people who work in low-light environments need to use synthetic vitamin D3. Although vitamin D is necessary but cannot be synthesized by the body, the active form of vitamin D3 is synthesized only when the skin is exposed to sunlight. Without vitamin D, the body will have to take calcium from the bone marrow, making bones weak and brittle, increasing the risk of osteoporosis. Vitamin D3 stimulates the absorption of calcium and phosphate from the small intestine, promotes the excretion of calcium from the bone marrow into the circulatory system, promotes the reabsorption of phosphate in the renal tubules, is an essential element for the development of bones and teeth. Cholecalciferol (Vitamin D3) is a fat-soluble vitamin, which is the active form of vitamin D that the body can use directly without going through a metabolic step.
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